Insulin resistance is a condition in which the cells in your body don't respond properly to insulin, a hormone produced by the pancreas that helps regulate blood sugar (glucose) levels. When cells become insulin resistant, they don't effectively absorb glucose from the bloodstream. Over time, this can contribute to the development of type 2 diabetes and other health issues like cardiovascular disease, fatty liver, decreased muscle mass, hormonal concerns, obesity and even osteoporosis (low bone density).